Pu Zhiqiang has handled numerous important cases in China. He represented individuals in several high-profile cases highlighting the abuses of the labour camp system often used to stifle free speech, including Tang Hui, who was sent to a labour camp in 2012 for seeking justice for the rape, kidnap and prostitution of her 11-year-old daughter. He represented Chinese blogger Fang Hong and college graduate Ren Jianyu, who commented or reposted comments critical of Chongqing authorities.
Pu also has been involved in defending media organizations, journalists and artists, including Ai Weiwei. The lawyer won a landmark victory for China Reform magazine in a defamation case seen as an important advance in the protection of independent media in China. He was also one of the defence lawyers for authors Chen Guidi and Wu Chuntao, who wrote a best-selling expose on rural corruption.